报告时间：2019年6月12日（星期三）下午15:00至17:00

报告地点：生物楼406会议室

报告人：张磊，第二军医大学

　　报告摘要：

　　The chemical diversity of natural products from plants has had a profound and lasting impact on human health with a variety of intriguing structures and biological activities. An understanding of how these molecules are formed would serve a dual role to enable a study of the in vivo function, as well as development of metabolic engineering or synthetic biology production platform to result in a sustainable supply of a drug. Due to lacking the information of genetic background, biochemical pathway elucidation in non-model system has often taken decades to complete. Next-gen sequencing technology enables revolutionary omics-driven approaches to understand and regulate valuable secondary metabolism in medicinal plant. Methods using systematic measurements to construct mathematical models of complex biological process from biological components and their interactions are currently being tested in this respect. We present herein a broadly applicable rapid biosynthetic gene discovery method using large datasets derived from genomics, transcriptomics, proteomics, and metabolomics to investigate the functions of key gene and transcript factor involved in metabolic network. Case study of gene discovery involved in phenylpropanoids biosynthesis and pathway regulation to engineer high level of active compounds in Isatis indigotica, one of a famous traditional Chinese medicinal herb will be presented.

　　报告人简介：

张磊，博士，第二军医大学药学院药用植物学教研室主任，中药学学科带头人，教授，博导。从事药用植物活性天然产物生物合成和代谢调控研究。2000年毕业于第二军医大学（学士），2007年获复旦大学遗传学博士，2010-2012年在加州大学戴维斯分校从事博士后研究。2006年入选上海市“青年科技启明星”，获上海市“浦江人才计划”（2013）和“优秀学术带头人计划”（2019）资助，2016年入选教育部“青年长江学者”。现任上海市植物生理与分子植物生物学学会副理事长，上海市植物学会药用植物与植物药专委会副主委。

　　联系人：18T6组 周雍进

　　联系电话：0411-84771060