报告时间：2012年12月24日（星期一）上午10：00

报告地点：生物楼学术报告厅

报告人：Dr. Qiang Hu

　　　 Laboratory for Algae Research and Biotechnology，College of Technology and Innovation，Arizona State University

报告摘要:

Many microalgae have the ability to synthesize and accumulate large amounts of storage neutral lipid mainly in a form of triacylglycerol (TAG) under stress (e.g., nutrient depletion, excess light). However, the pathways and regulatory mechanisms for TAG formation are poorly understood. Lipid bodies (LB) rich in TAG are subcellular organelles in microalgae. LB are limited in number and size when cells grow vigorously and are reproductive, but the number and size of LB may increase dramatically under stress. Although this phenomenon has been often observed, little is known about the formation and function of LB, especially under stress conditions. In this study, multiple pathways for TAG synthesis and the biogenesis and function of LB in Chlamydomonas reinhardtii were investigated using a systems biology approach. Several lines of evidence, including that obtained from confocal fluorescence and electron microscopy, and functional genomic, proteomic and lipidomic analyses of intact cells and isolated LB, suggest that phospholipid:diacylglycerol acyltransferase is to a large extent responsible for TAG synthesis under favorable culture conditions, whereas the Kennedy pathway plays a more important role in TAG formation under stress. The majority of LB are derived from and physically connected with the chloroplast. The intimate association of some LB with endoplasmic reticulum (ER) indicates that ER may be another route of LB formation. Our preliminary results indicate that LB are complex, dynamic organelles that interact actively with chloroplast, endoplasmic reticulum, and mitochondria. Genetic manipulation of key genes/enzymes involved in lipid synthesis for trait improvement will be demonstrated. Metabolic engineering of genes associated with LB and closely related organelles that are involved in lipid metabolism may further enhance the synthesis and sequestration of TAG into LB and thus increase overall TAG production.

报告人简介:

Dr. Qiang Hu is a Professor and co-Director of the Arizona Center for Algae Technology and Innovation and Laboratory for Algae Research and Biotechnology at ASU. He has over 25 years of experience in fundamental and applied research on algae in topics ranging from photosynthesis, biosynthesis of lipids and carotenoids, growth physiology of high-density algal culture, photobioreactor system design, and application of algal mass culture technology for biofuels and chemicals, and for environmental bioremediation. He has authored or co-authored numerous research articles and book chapters and is the inventor or co-inventor on 20 patents and patent disclosures. Dr. Hu is an Associate Editor of the international journals Algae and Phycologia and an editorial board member of Algal Research and Journal of Applied Phycology. He serves as a member of Board of Directors of Algae Biomass Organization and a number of review panels for the DOE, NSF, EPA, USDA and NOAA bioenergy programs and was a contributor to the U.S. DOE National Algal Biofuels Technology Roadmap. Dr. Hu’s work was recognized in Time Magazine under the title “Green Crude” and listed as one of the “50 Best Inventions of 2008”. He received the 2007 Innovator of the Year Award from Arizona Technology Enterprises, was recognized with the Innovator of the Year-Academia Award at the 2009 Governor’s Celebration of Innovation, and was the recipient of the 2010 Award for Research Excellence from the Arizona BioIndustry Association.　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　.

报告联系人：1812组 薛松（9069）