报告时间：2013年9月17日（星期二）下午 13:30
报告地点：催化楼一楼会议室
报告人：Professor Choon-Hong Tan
School of Physical & Mathematical Sciences, Division of Chemistry and Biological Chemistry
Nanyang Technological University, 21 Nanyang Link, Singapore 637371
Email: choonhong@ntu.edu.sg
报告人简介：
Choon-Hong Tan，男，1971年生，博士，新加坡南洋理工大学副教授，主要研究领域为有机化学、药物化学与生物材料化学，目前研究课题以小分子有机催化为主。Tan教授1999年在英国剑桥大学化学系获博士学位，2000年至2003年在美国哈佛大学从事博士后研究，2003年至2012年在新加坡国立大学化学系工作。2012年至今任新加坡南洋理工大学副教授。获得的主要奖项有：2008年“英国-新加坡科技合作奖”，2009年“杰出年轻化学家奖”、“杰出年轻科学家奖”及“CRISP奖”，2011年“葛兰素史克-新加坡化学会有机化学奖”等。目前已在包括Angew. Chem. Int. Ed.和J. Am. Chem. Soc.在内的著名国际学术期刊上发表论文70余篇，拥有3项发明专利。
报告摘要：
We have been active to develop chiral guanidine as general Br？nsted base catalyst. We found them to be excellent enantioselective catalysts for Michael, Phospha-Michael and Diels-Alder reactions. In this seminar, we would like make a summary of these reaction and highlight some reactions relating to the enantioselective transfer of protons. The conjugate addition of arylthiol to 2-phthalimidoacrylate and 1,3-proton shift reaction leading to chiral allenes are two examples. Application of these method for the synthesis of natural products will also be discussed. Recent progress in phase transfer catalysis will also be reported.
Related publications
1. D. Leow, S. Lin, S. K. Chittimalla, X. Fu and C.-H. Tan, Enantioselective protonations catalyzed by chiral bicyclic guanidine, Angewandte Chemie International Edition English, 2008, 47, 5641–5645. (Highlighted by Synfacts 2008, 9, 0933-0933; contributors: Benjamin List, Frank Lay; Highlighted on ChemInform 2008, 39, DOI: 10.1002/chin.200847194.)
2. H. Liu, D. Leow, C.-H. Tan, Enantioselective synthesis of chiral allenes by guanidine-catalyzed isomerization of alkynes, Journal of the American Chemical Society, 2009, 131, 7212–7213. (Highlighted by Synfacts 2009, 7, 0794-0794; contributors: Benjamin List, Steffen Müller)
3. T. Ma, X. Fu, C. W. Kee, L. Zong, Y. Pan, K.-W. Huang, C.-H. Tan, Pentanidium catalyzed enantioselective phase transfer conjugate addition reactions, Journal of the American Chemical Society, 2011, 133, 2828–2831. (Highlighted by Synfacts 2011, 5, 0556-0556; contributors: Benjamin List, Saihu Liao)
4. J. Wang, J. Chen, C. W. Kee, C.-H. Tan, Bicyclic Guanidine-Catalyzed Enantiodivergent γ-Selective Asymmetric Allylic Amination, Angewandte Chemie International Edition, 2012, 51, 2382 –2386.
报告联系人：203组 余正坤（9227）
