报告时间：2014年4月3日（星期四）上午10：00

报告地点：生物楼406房间 

　报告人：Shawn S.-C. Li教授 

　　加拿大西安大略大学教授 　　  

　　报告摘要： 

　　Epigenetics refers mainly to the study of DNA and histone modifications and their role in regulating the gene transcriptional program. Aberrant epigenetic changes have been associated with a plethora of human diseases, notably cancer. Histones around which the DNA is wrapped in chromatin is subject to numerous modifications on specific types of amino acids, including lysine and arginine, by histone modifying enzymes. Interestingly, a number of recent studies indicate that non-histone proteins are also substrates of these enzymes. These studies therefore expand epigenetic modifications to non-histone proteins and call for further research into this new area in order to understand the role of protein methylation in general as well as their functions in specific cellular processes. The Li lab has recently developed a method that combines mass spec, peptide array and bioinformatics to systematically identify Lys methylation events occurring on histone and non-histone proteins. Dr. Li will present data on how this method allows the identification of a methylation-driven interactome associated with DNA damage repair and how dynamic methylation regulates stem cell differentiation.

　　报告人简历： 

I.  EXPERTISE & RESEARCH INTERESTS

　　Cellular signal transduction, Proteomics (eg., peptide and protein microarrays, mass spectrometry), Identification and characterization of post-translational modifications (eg., phosphorylation, methylation, acetylation), Molecular basis of oncogenesis and drug resistance, Novel therapeutics. 

II. EDUCATION & TRAINING

　　1995-2000  Postdoctoral Fellow.  Lunenfeld-Tanebaum Research Institute, Mount Sinai Hospital, Toronto. Supervisor: Dr. Tony Pawson. 

　　1995  Ph.D, University of Toronto, Department of Biochemistry. 

　　1988  MSc, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Science. 

　　1985  BSc, Department of Chemistry, Peking University, Beijing. 

　　III. EMPLOYMENT 

　　2011-present, Professor, Department of Biochemistry, cross-appointed to the Department of Oncology, Western University (or University of Western Ontario), London, Ontario, Canada. 

　　2005-2010  Associate Professor, Department of Biochemistry, Western University. 

　　2000-2005  Assistant Professor, Department of Biochemistry, Western University 

　　2000-present   Scientist, Child Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada 

　　IV. AWARDS, HONOURS, FELLOWSHIPS 

　　2013    Top 10 Research Stories of 2013, Canadian Cancer Society Research Institute 

　　2011-2016  Canada Research Chair in Functional Genomics and Cellular Proteomics (renew)   

　　2006-2011  Canada Research Chair in Functional Genomics and Cellular Proteomics (Tier II) 

　　2004    Boehringer Ingelheim Young Investigator Award for the Biological Sciences  

　　2004    Dean’s Award of Excellence (Research). Schulich School of Medicine and Dentistry, University of Western Ontario.  

　　2001    Premier’s Research Excellence Award (PREA, Government of Ontario) 

　　2001    Harold E Johns Award. National Cancer Institute of Canada (NCIC). 

　　2001-2007    Research Scientist Award. NCIC 

　　1999-2000  Centennial Fellowship, Medical Research Council of Canada (MRC). 

　　1995-1998  Fellowship, Medical Research Council of Canada. 

　　1995-1998  Fellowship, National Cancer Institute of Canada (NCIC) (declined).   

　　1995    Young Investigator Award, American Peptide Society. 

　　1994    RESTRACOM Award for Scientific Merit, The Hospital for Sick Children, Toronto.  

　　1993      Young Investigator Award, American Peptide Society. 

　　报告联系人：1809组 王璐（9620）