Asymmetric Synthesis of Chiral Molecules Using Catalysts Based on Non-precious and Environmentally Friendly Metal--Discovery, Development and Creativity

     报告时间:2014年328日(周五)上午10:00 

   报告地点:能源楼一号楼一楼会议室 

  报告人:Dr. Weiwei Zuo (左伟伟) 

  Department of Chemistry, University of Toronto, Canada 

   个人简介: 

  Education: 

  Ph.D. in Organometallics and Polymer Chemistry, Institute of Chemistry, CAS, China, Sept. 2005-Jun. 2008.  

  Master of Polymer Physics, Donghua University, China, Sept.2002-Mar. 2005  

  Bachelor of Science in Chemistry, Suzhou University, China, Sept. 1998-Jun. 2002  

  Employment summary:  

  Postdoctoral Associate in Organometallics and Catalysis, University of Toronto, Canada, Nov. 2011-present  

  Postdoctoral Associate in Organometallics and Catalysis, University of Strasbourg, France, Jan. 2009-Jun. 2011.  

  Areas of primary scientific interest: 

  Green Chemistry, Asymmetric Catalysis, Iron based Organometallic Chemistry, Polymerization, Cross-Coupling Reactions Catalyzed by Iron based Catalysts.  

  报告摘要: 

  Metal based homogeneous catalysts are used in the pharmaceutical, fragrance, flavoring, and fine chemicals industries for the synthesis of enantiomerically pure organic molecules such as alcohols, amines, and amino acids. Iron is an element essential to life and is abundant in mineral ores and thus its use is preferable for economic and health reasons. We validate a prior mechanistic hypothesis that partially saturated amine(imine)diphosphine ligands (P-NH-N-P) activate iron to catalyze the asymmetric reduction of the polar bonds of ketones and imines to valuable enantiopure alcohols, amines and amino acids, with isopropanol as the hydrogen donor, at turnover frequencies as high as 200 per second at 28°C. The author will share the expedience with the audience especially the students how to do research creatively, including where comes the initial idea, how the science was developed and what should we do in order to to a high-quality research.  

  报告联系人:DNL1901组 谢冬(9583

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