报告题目： 1: Metabolomics / Lipidomics in Diabetes Research-Key to Personalized Medicine

　　报告人：Prof. Dr. Rainer Lehmann (Central Laboratory, Dept. of Internal Medicine IV, University Hospital of Tuebingen, Germany)

　　报告题目：2: The exercise secretome-an endogenous medicine to treat metabolic disorders?

　　报告人：Prof. Dr. Cora Weigert（Central Laboratory, Dept. of Internal Medicine IV, University Hospital of Tuebingen, Germany）

　　报告题目：3: PLS and OPLS analysis in metabolomics

　　报告人：Mohamed TRIBA (Faculty Health, Medicine and Human Biology, University Paris 13)

　　报告时间: 2014年6月18日星期三 下午13:30

　　报告地点：生物楼一楼学术报告厅

　　报告人简介：

　　Prof. Dr. Rainer Lehmann

　　Scientific issues：

　　Metabolomic profiling

　　Pathobiochemistry of metabolic changes and insulin signal transduction in the prediabetes

　　Identifying new predictive diagnostic metabolite biomarkers

　　Development and application of innovative techniques in basic research and clinical chemistry

　　Techniques：

　　Various electrophoretic, chromatographic, immunological and mass spectrometric methods, as well as molecular and cell culture methods are used in our working group. In addition we deal with the development and application of new analytical techniques. In addition to studies of cell culture assays, we perform experimental animal studies, as well as the analysis of body fluids and tissues of human origin.

　　Prof. Dr. Cora Weigert

　　Scientific issues

　　Understanding of the underlying molecular mechanisms is necessary for the prevention and treatment of insulin resistance. These research objectives are edited with cell culture (especially for skeletal muscle, liver) and mouse models. A "Training Center for mice" examines the molecular basis of the importance of sport for the maintenance of a balanced metabolism, such as the importance of Myokinen (signal molecules released from working skeletal muscle). Another focus is the identification and functional characterisation of posttranslational modifications of the insulin receptor substrates.

　　Current projects

　　Metabolic function of Interleukin-6 Myokins

　　Regulation of physiological insulin signal shutdown by serine/Threoninkinasen

　　Importance of serine/Threoninphosphorylierungen for the role of IRS-1 and IRS-2

　　Regulation of gene activation in skeletal muscle through sports and fasting

　　Mohamed TRIBA

　　He did my PhD thesis in the laboratory of Molecular Physical Chemistry of Biological Membranes at the Institute of Physical and Chemical Biology (Paris). After his PhD, he get a post-doctoral position in the laboratory where applied solid-state NMR for the study of membrane proteins. In 2007,He came back to France, in the European Center for High Field NMR in Lyon. Since 2009, he is assistant professor in the university of Paris 13. I work. Since few years, he developed in-house routines to automatize processing and statistical analyses of metabolic data.

　　报告联系人：1808组 许国旺 （9530）