报告时间：2014年10月17日(星期五) 上午9:30  

　　报告地点：生物楼一楼小会议室  

　　　　报告人：黄居正博士 伦敦帝国理工大学外科手术和癌症系 　　  

　　报告摘要：

    Breath analysis is a diagnostic modality with few routine applications in clinical practice. Notable examples include the measurement of ¹³C urea for Helicobacter pylori (H.pylori) bacterium, hydrogen breath testing for small bowel bacterial overgrowth and exhaled nitric oxide in asthma. However, human breath is also a complex gaseous biological sample containing over 250 volatile organic compounds (VOCs). In recent years, the role of VOCs in cancer has been investigated using both innovative and conventional methods. Several studies employing Gas-Chromatography Mass-Spectrometry (GC-MS) or Ion Mobility Mass spectrometry have identified potential VOCs of interest within exhaled breath in cancer. Other technological advances have resulted in the development of novel chemical analytical techniques such as selected ion flow tube mass spectrometry (SIFT-MS), both of which offer real time quantification of VOCs.  

　　Esophageal and gastric malignancies account for 15% of cancer-related deaths globally.¹ Eight of ten patients will die in five years even after surgical operations. 50% of esophageal and gastric cancer patients are Chinese. The lack of ‘alarm’ symptoms until the disease is at a more advanced stage contribute to these poor statistics. However, diagnosis of these cancers at a treatable stage is associated with a significant survival benefit. Thus, there remains an important clinical need to develop novel methods for early disease detection in esophageal and gastric cancer. 

　　At St Mary’s hospital, we have conducted the up to date largest exhaled breath analysis for esophageal and gastric cancer patients. A panel of VOCs have been identified as potential biomarkers and a diagnosis prediction model was constructed upon the findings to demonstrate the potential of exhaled breath analysis as a non-invasive tool for the disease diagnosis.　 

　　报告人简介：  

　　黄居正，2007年获得英国伦敦大学学院（University College London, UCL）化学学士学位。2011年于剑桥大学化学系博士毕业，从事悬臂梁矩阵传感器检测有机磷化物方面的研究工作。从2011年10月至今，于伦敦帝国理工大学外科手术和癌症系从事癌症诊断的科研工作。主要研究方向是利用质谱（GCMS, SIFT-MS, TOF-MS），对包括包括癌症病人在内的多种病患样品（包括，呼吸气，胃液，尿液,组织等）的定性和定量分析，从而发展新型癌症诊断技术。  

　　研究领域： 

　　用于临床病人样品分析的有机质谱：1. SIFT-MS；2.GC-MS；3.Quadrupole orthogonal-acceleration time-of-flight Xevo G-2S mass spectrometer. 

　　传感器：Microcantilever, 悬臂梁矩阵传感器