报告时间：2016年5月9日(星期一)上午9:00 

　　报告地点：能源基础楼一楼会议室 

　　报告人：Dr. John M. Slattery 

　　The University of York, UK

　　报告人简介： 

　　 Dr. John Slattery is a senior lecturer in chemistry at the University of York, UK. He received his Ph.D. from the University of Bristol, UK (2005).  He worked at école Polytechnique Fédérale de Lausanne, Switzerland (2005-2006) and Albert-Ludwigs Universit？t Freiburg, Germany (2006-2007) under Alexander von Humboldt Fellowship. His research focuses on using a synergistic experimental and computational approach to design new molecular systems for a range of applications. 

　　报告摘要： 

　　Understanding the mechanism and scope of novel organometallic reactions is fascinating from a fundamental perspective, but also provides crucial insight that can be used to inform the design of new stoichiometric and catalytic synthetic methodologies. In recent work, we showed that unusual pyridylidene complexes can play an active role in catalysis, in this case C-H functionalization of pyridine. While exploring the reactivity of a catalyst deactivation product in this system we uncovered some unexpected, but exciting reactivity. 

　　Reaction with a range of electrophilic fluorinating agents leads to the formation of [3]+ via an unprecedented outer-sphere electrophilic fluorination (OSEF) mechanism. This contrasts strongly with related Pd-based electrophilic fluorination reactions, which typically proceed via the formation of a metal-fluoride intermediate.3 Subsequent work in York has shown that a range of metal alkynyl and alkenyl complexes undergo fluorination (and trifluoromethylation) via OSEF. A detailed discussion of the mechanistic features of these systems and the reactivity of the fluorinated organometallic species will be presented, based on the results of both experimental and computational studies. This fundamental work has significant potential to underpin the development of novel metal-mediated fluorination methodologies and preliminary results in this direction will also be discussed. 

报告联系人：DNL21T2 冯璐（9167）