报告时间：2016年4月19日，星期二，上午09:00 

　　报告地点：能源基础楼一楼会议室 

　　报告人：Prof. Dr. Philippe Schmitt-Kopplin 

　　Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum Muenchen, Germany 

　　Professional experiences: 

　　·  2011 - now Director of the independent research unit "Analytical Biogeochemistry" at the Helmholtz Zentrum München, Munich, Germany 

　　·  2009 - 2011 Director of the research unit "BioGeoChemistry and Analytics" in the Institute of Ecological Chemistry, Helmholtz Zentrum München, Munich, Germany 

　　· 2001 - 2009  Permanent position, group leader: "BioGeomics", at the Institute of Ecological Chemistry, GSF, Munich , Germany 

　　· 1996 - 2001 Young-scientist at the "Institut für ？kologische Chemie der GSF", Munich, Germany 

　　· 1995 Research associate from the US-National Research Council stipend, US-Environmental Protection Agency, Athens, Georgia, USA 

　　Education: 

　　· Nov. 2002   Habilitation at the Wissenschaftszentrum Weihenstephan für Ern？hrung, Landnutzung und Umwelt der Technische Universit？t München in ？kologische Chemie und Umweltanalytik. Teaching actvities at TUM 

　　· Oct. 1996   Doctor theses at the ？Institut National Polytechnique de Lorraine (INPL), Nancy , France 

　　· Mai 1995    Doctor theses at the ？Technischen Universit？t München“, Germany , 

　　· 1987 - 1990 Institut National Polytechnique de Lorraine (INPL), Ecole Nationale Supérieure d′Agronomie et des Industries Alimentaires (ENSAIA), Nancy, (F)  

　　Reviewer activities:  

　　Various European science agencies including more specifically the frensh ANR (regular and LABEX Program) and DFG.  

　　Peer reviewed publications: 

　　11 review papers 

　　269 original publications 

　　36 Book Chapter / Book Contributions / Book Reviews 

　　报告摘要： 

　　(Ultra)High resolving modern analytics have been confirmed as essential in the chemical/metabolic description and understanding on a molecular level of biological and environmental systems. Especially the data integration of orthogonal technologies such as direct injection (DI) ion cyclotron resonance Fourier transform mass spectrometry (FT-ICR-MS), which provides unrivalled compositional resolution, ultra-performance liquid chromatography mass spectrometry (UHPLC-MS), which increases the scope of detectable metabolites and allows the separation between isomers and NMR spectroscopy which provides detailed structural compositions has been ideally followed for the chemical diversity description in organic geochemistry and metabolomics. Powerful statistical tools and relevant databases are used in combination to the analytical platforms (FT-ICR-MS, UHPLC-MS, NMR) in order to provide an unprecedented synoptic description of the chemical complexity. 

　　Metabolomic, as the comprehensive study of metabolic reactions in biology is growing very rapidly and integrates the knowledge of earlier developed Omics-branches. ICR-FT/MS describes highly complex mixtures on the level of the elementary composition distribution and is shown in this presentation as a dedicated tool to understand the composition and processes on a molecular level in various study fields from food chemistry, biology, organic geochemistry towards interplanetary chemistry. 

　　We present here the analytical pipeline of DI-FT-ICR-MS for the profiling of any complex organic mixture with a focus on the possibilities in resolution and dynamic range and limits of the approach that is expended into many other metabolomics and data driven systems biology in health and environment.  　  

  报告联系人：DNL2003组  胡春秀（9396）